2,6-DIAMINO-3-(2,3,5-TRICHLOROPHENYL)-PYRAZINE synthesis

Yield:212778-82-0 2.29 g (88%)

Reaction Conditions:

in hydrogenchloride;water;

Steps:

10 10.

10. 2,6-Diamino-3-(2,3,5-trichlorophenyl)pyrazine A suspension of 2-amino-6-acetamido-3-(2,3,5-trichlorophenyl)pyrazine (2.97 g, 8.96*10^-3 mole) in 12M hydrochloric acid (1.31 ml) and water (4.04 ml) was fluxed for 1.75 hrs. The cooled mixture was then basified with 0.880 aqueous ammonia (5 ml) and extracted with chloroform (3*50 ml). The combined chloroform extracts were dried over anhydrous magnesium sulphate, filtered and the filtrate evaporated down in vacuo at 80° C. Yield 2.29 g (88%), M.p. 178-180° C.

References:

US6255307,2001,B1