ChemicalBook CAS DataBase List 2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole

2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole synthesis

11synthesis methods

Product Name:2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole
CAS Number:106006-83-1
Molecular formula:C7H11N3S
Molecular Weight:169.25

104618-33-9 Synthesis

2-Amino-6-phthalimido-4,5,6,7-tetrahydro benzothiazole

104618-33-9
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2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole

106006-83-1
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Yield: 88.46%

Reaction Conditions:

with triethylamine;hydrazine in isopropyl alcohol for 2 - 3 h;Heating / reflux;

Steps:

5
100gm(0.3344mole) 2-amino-6-phthalimido-4,5,6,7-tetrahydro benzothiazole was suspended in 500ml isopropyl alcohol. Add 20.05gm(0.4010mole) hydrazine hydrate and 7.26gm (0.0718mole) Triethylamine. Reflux for 2-3hrs. Cool the mass to 10° C , Filter the slurry and wash with chilled isopropyl alcohol. Isolated mixture of compounds are recrystalize in absolute alcohol YIELD: 50gm(88.46%)

References:

ALEMBIC LIMITED WO2006/3677, 2006, A1 Location in patent:Page/Page column 10; 18

106006-80-8 Synthesis