2,6-dibromo-4-phenyl-phenol synthesis
- Product Name:2,6-dibromo-4-phenyl-phenol
- CAS Number:4400-05-9
- Molecular formula:C12H8Br2O
- Molecular Weight:328
Yield:92-03-5 89%
Reaction Conditions:
Stage #1: 4-Phenylphenolwith toluene-4-sulfonic acid in methanol; for 0.166667 h;
Stage #2: with N-Bromosuccinimide in methanol; for 0.416667 h;
Steps:
3.2. General Procedure for Batch Reaction Conditions in ACS-Grade Methanol
General procedure: A solution of the starting material (~10 mmol) and pTsOH (10 mol %) in MeOH (1.0 mL per mmol starting material) was stirred for 10 min, then a solution of NBS (100 mol %; recrystallized from H2O) in MeOH (0.1 M) was added dropwise over 20 min from a foiled reaction flask. The reaction mixture was stirred for a further 5 min and then concentrated in vacuo. The resultant residue was purified using column chromatography (CH2Cl2, or 1% MeOH in CH2Cl2). 3.3. Characterization of Products2-Bromo-4-methylphenol (10) [23]: 10.1 mmol; 1.73 g (92%);
References:
Georgiev, David;Saes, Bartholomews W.H.;Johnston, Heather J.;Boys, Sarah K.;Healy, Alan;Hulme, Alison N. [Molecules,2016,vol. 21,# 1,art. no. 21010088]
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