2,6-Dichloro-3-nitroacetophenone synthesis

Yield:223785-76-0 89%

Reaction Conditions:

with sulfuric acid;nitric acid at -30; for 1 h;

References:

Verma, Vishal A.;Wang, Lan;Labadie, Sharada S.;Liang, Jun;Sellers, Benjamin D.;Wang, Jian;Dong, Liting;Wang, Qiuyue;Zhang, Shuang;Xu, Zhongya;Zhang, Yexia;Niu, Yanan;Wang, Xinxin;Wai, John;Koehler, Michael F. T.;Hu, Huiyong;Alexander, Mary Kate;Nishiyama, Mireille;Miu, Anh;Xu, Yiming;Pang, Jodie;Katakam, Anand K.;Reichelt, Michael;Austin, Cary D.;Ho, Hoangdung;Payandeh, Jian;Koth, Christopher M. [Journal of Medicinal Chemistry,2022,vol. 65,# 5,p. 4085 - 4120] Location in patent:supporting information