ChemicalBook CAS DataBase List 2,6-DICHLORO-5-FLUORONICOTINAMIDE

2,6-DICHLORO-5-FLUORONICOTINAMIDE synthesis

5synthesis methods

Product Name:2,6-DICHLORO-5-FLUORONICOTINAMIDE
CAS Number:113237-20-0
Molecular formula:C6H3Cl2FN2O
Molecular Weight:209.01

2,6-Dichloro-5-fluoronicotinamide can be used as organic intermediate and pharmaceutical intermediate, mainly used in laboratory research. It can be synthesized by amination of 2,6-Dichloro-5-fluoronicotinic acid, thionyl chloride and TEA.

82671-02-1 Synthesis

2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

82671-02-1
228 suppliers
$10.00/5g

113237-20-0
192 suppliers
$5.00/250mg

Yield:113237-20-0 99.5%

Reaction Conditions:

with sulfuric acid at 62; for 1 h;

Steps:

1 Step 1) 2,6-Dichloro-5-fluoronicotinamide
Weigh 2,6-dichloro-5-fluoro-pyridine-3-carbonitrile (24.8 g, 130 mmol)Concentrated sulfuric acid (125 mL) was added to a 500 ml flask, and the mixture was heated to 62 ° C for 1 hour.After cooling to room temperature, the reaction solution was poured into ice water (800 mL) and ethyl acetate (300 mL×4).The organic phase was washed successively with water (100 mL), saturated sodium bicarbonate (100 mL) and brine (50 mL).Dry over anhydrous sodium sulfate.Filtered, the filtrate was dried,A pale yellow solid (27.0 g, 99.5%).

References:

Guangdong Dongyangguang Pharmaceutical Co., Ltd.;Wang Xiaojun;Zuo Yinglin;Yu Chuan;Yang Chuanwen;Wang Jiancheng;Li Jing;Cao Shengtian;Wu Fangyuan;Zhang Yingjun;S ·geerdeman CN108690016, 2018, A Location in patent:Paragraph 0366; 0368; 0369

FullText

82671-06-5 Synthesis