2,6-DICHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE synthesis

Yield:-

Reaction Conditions:

with hydroxylamine hydrochloride;potassium carbonate in ethanol at 20;Reflux;

Steps:

2.1 1) Synthesis of (Z)-2,6-dichloro-N'-hydroxybenzamidine

40ml of ethanol as a solvent,2.523g (0.18mol) of hydroxylamine hydrochloride was added to a 250ml four-neck flaskStir well and start dropping 9.33g (0.088mol) sodium carbonate solution at room temperature, and add 12.27g (0.08mol) 4-chlorobenzonitrile dropwiseStir at room temperature for 2hRaise the temperature to reflux again.After the reaction is completed, it is vacuum-evaporated to ethanol-free overflow.Salt obtained (Z) -4- chloro -N'- hydroxybenzimidamide,

References:

CN106349232,2017,A Location in patent:Paragraph 0066-0068