![](/CAS/GIF/40381-90-6.gif)
2,6-Dichloronicotinonitrile synthesis
- Product Name:2,6-Dichloronicotinonitrile
- CAS Number:40381-90-6
- Molecular formula:C6H2Cl2N2
- Molecular Weight:173
![2,6-Dichloronicotinamide](/CAS/GIF/62068-78-4.gif)
62068-78-4
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$20.00/250mg
![2,6-Dichloronicotinonitrile](/CAS/GIF/40381-90-6.gif)
40381-90-6
191 suppliers
$6.00/250mg
Yield:40381-90-6 89%
Reaction Conditions:
with tetraethylammonium chloride;trichlorophosphate at 80; for 24 h;
Steps:
General preparation of carbonitriles 8 and 14.
General procedure: The appropriate carboxamide 7 or 13 (189 mg, 0.99 mmol) was subjected to catalytic amounts of tetraethylammonium chloride (5% w/w) and POCl3 (5 ml) and heated under reflux at 80°C for 24 h. Excess POCl3 was removed in vacuo to leave a crude residue which was diluted with dichloromethane (10 ml) and filtered. The filtrate was washed successively with saturated aqueous K2CO3 (2 x 5 ml) and distilled water (5 ml). After drying over anhydrous Na2SO4, the solvent was evaporated to yield carbonitrile 8 or 14 which was sufficiently pure for use in the next reaction without purification. 2,6-Dichloronicotinonitrile (8)31 2,6-Dichloronicotinonitrile (8) was isolated as an off-white solid (152 mg, 89% yield). 1H NMR (300 MHz, CDCl3) δ 7.95 (d, J 8.1 Hz, 1H), 7.43 (d, J 8.1 Hz, 1H).
References:
Basson, Adriaan E.;Bode, Moira L.;Changunda, Charles R. K.;Rousseau, Amanda L. [Arkivoc,2021,vol. 2020,# 3,p. 152 - 170]
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76175-82-1
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![2,6-Dichloronicotinonitrile](/CAS/GIF/40381-90-6.gif)
40381-90-6
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$6.00/250mg
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91467-46-8
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![2,6-Dichloronicotinonitrile](/CAS/GIF/40381-90-6.gif)
40381-90-6
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![2 6-DICHLOROPYRIDINE-3-CARBOXALDEHYDE](/CAS/GIF/55304-73-9.gif)
55304-73-9
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$6.00/1g
![2,6-Dichloronicotinonitrile](/CAS/GIF/40381-90-6.gif)
40381-90-6
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$6.00/250mg
![2,6-dihydroxy-3-cyanopyridine](/CAS/GIF/35441-10-2.gif)
35441-10-2
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![2,6-Dichloronicotinonitrile](/CAS/GIF/40381-90-6.gif)
40381-90-6
191 suppliers
$6.00/250mg