2,6-DIFLUORO-N-HYDROXY-BENZAMIDINE synthesis

Yield:296766-98-8 85%

Reaction Conditions:

with hydroxylamine hydrochloride;triethylamine in ethyl acetate at 80; for 4 h;

Steps:

1.2 (2) Synthesis of intermediate II:

Add 0.11 mol (7.65 g) to a 250 mL reaction flask.Hydroxylamine hydrochloride,50g of ethyl acetate as a solvent,Then add 0.11 mol of triethylamine (11.11g)And 0.1 mol (13.9 g) of 2,6-difluorobenzonitrile,Stir,Heating at 80 ° C for 4 h,TLC tracking reaction is complete,cool down,Filtering,The filtrate was evaporated to remove EA.cool down,Obtained white solid compound II 14.62g,The yield was 85%.

References:

CN109320506,2019,A Location in patent:Paragraph 0017; 0024; 0025; 0026