2,6-Difluoro-N-methoxy-N-methylbenzamide synthesis
- Product Name:2,6-Difluoro-N-methoxy-N-methylbenzamide
- CAS Number:937601-82-6
- Molecular formula:C9H9F2NO2
- Molecular Weight:201.17
6638-79-5
573 suppliers
$6.00/25g
18063-02-0
253 suppliers
$12.00/5g
937601-82-6
21 suppliers
$23.00/250mg
Yield:937601-82-6 96%
Reaction Conditions:
Stage #1: N,O-dimethylhydroxylamine*hydrochloridewith triethylamine in dichloromethane at 0;Inert atmosphere;
Stage #2: 2,6-difluorobenzoylchloride in dichloromethane at 0 - 20;Inert atmosphere;
References:
Kishore Kumar;Chavarria, Gustavo E.;Charlton-Sevcik, Amanda K.;Arispe, Wara M.;MacDonough, Matthew T.;Strecker, Tracy E.;Chen, Shen-En;Siim, Bronwyn G.;Chaplin, David J.;Trawick, Mary Lynn;Pinney, Kevin G. [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 4,p. 1415 - 1419] Location in patent:supporting information; experimental part