2,6-diiodo-4-methylaniline synthesis

7synthesis methods

Product Name:2,6-diiodo-4-methylaniline
CAS Number:64662-57-3
Molecular formula:C7H7I2N
Molecular Weight:358.95

106-49-0
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Yield:64662-57-3 92%

Reaction Conditions:

with iodine in chloroform at 0; for 2 h;Inert atmosphere;

Steps:

1-2 Preparation Example 1-2: Synthesis of Compound 1-B

The compound p-toluidine (34.3 g, 0.32 mol) was thoroughly dissolved in 300 mL of chloroform under a nitrogen atmosphere, and then 0.64 mol of iodine was added to the resulting solution at 0° C., followed by stirring for 2 hours. After the organic layer was extracted with a solution (1 mol, 300 mL) of sodium thiosulfate, the organic layer was thoroughly distilled and purified by column chromatography (chloroform/hexane) to prepare the compound 1-B (105.7 g, yield: 92%).MS[M+H]⁺=358

References:

US2020/216475,2020,A1 Location in patent:Paragraph 0129-0131