2-(6-METHYL-1-BENZOFURAN-3-YL) ACETIC ACID synthesis
- Product Name:2-(6-METHYL-1-BENZOFURAN-3-YL) ACETIC ACID
- CAS Number:142917-39-3
- Molecular formula:C11H10O3
- Molecular Weight:190.2
41321-75-9
0 suppliers
inquiry
142917-39-3
24 suppliers
inquiry
Yield:142917-39-3 95%
Reaction Conditions:
with sodium hydroxide in water;Reflux;Perkin Coumarin Rearrangement;
Steps:
Synthesis of (5-Methyl-benzofuran-3-yl)-acetic Acid (5a)
General procedure: The substituted-4-bromomethylcoumarin 4 (10 mM) was refluxed in 1M NaOH (100 mL) for1-2 h (monitored by TLC). Th ereaction mixture was cooled and neutralized with 1M HCl ,and then the obtained product was filtered and dried. The obtained products were sufficiently pure and hence were not recrystallized. Mp 97-98 °C (literature mp 98-100 °C),[15] yield 95%; IR (KBr, ν in cm-1): 3439 (br, OH), 1722 (C=O); 1H NMR (400 MHz, DMSO-d6): δ 2.39 (s, 3H, C5-CH3), 3.65 (s, 2H, C3-CH2), 7.11 (d, J=8.4 Hz, 1H, C6-H), 7.37 (d, J=0.4 Hz, 1H, C4-H), 7.42 (d, J=8.4 Hz, 1H, C7-H), 7.83 (s, 1H, C2-H), 12.46 (s, 1H, COOH); 13C NMR (400 MHz, DMSO-d6): 20.88, 28.95, 110.74, 113.68, 119.71, 125.42, 127.81, 131.39, 143.44, 152.92, 171.92. LCMS m=z: 191 [M+1]. Anal. calcd. for C11H10O3: C, 69.46; H, 5.30. Found: C, 69.38; H, 5.28.
References:
Basanagouda, Mahantesha;Narayanachar;Majati, Iranna B.;Mulimani, Shiddappa S.;Sunnal, Satish B.;Nadiger, Rohit V.;Ghanti, Ashok S.;Gudageri, Siddeshwar F.;Naik, Ravi;Nayak, Akshata [Synthetic Communications,2015,vol. 45,# 19,p. 2195 - 2202] Location in patent:supporting information
82156-60-3
1 suppliers
inquiry
142917-39-3
24 suppliers
inquiry
20895-41-4
16 suppliers
inquiry
142917-39-3
24 suppliers
inquiry
108-39-4
467 suppliers
$13.00/25g
142917-39-3
24 suppliers
inquiry