2,7-Diazaspiro[3.5]nonane, 7-Methyl- synthesis

5synthesis methods

Product Name:2,7-Diazaspiro[3.5]nonane, 7-Methyl-
CAS Number:135380-50-6
Molecular formula:C8H16N2
Molecular Weight:140.23

2,7-Diazaspiro[3.5]nonane-2-carboxylic acid, 7-Methyl-, 1,1-diMethylethyl ester

1093066-77-3
5 suppliers
inquiry

135380-50-6
22 suppliers
$496.07/5MG

Yield:-

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 0 - 20; for 3 h;

Steps:

A26 Preparation of intermediate 190

Intermediate 189 was dissolved in DCM (15 mL) and cooled to 0°C. The suspension was treated with TFA (3.1 mL) dropwise. The mixture was stirred at room temperature for 3 hours The solvents were evaporated to dryness and the product was triturated with ether to give crude intermediate 190 (0.273 g, 100% yield), which was used a such without further purification.

References:

WO2017/153186,2017,A1 Location in patent:Page/Page column 132