ChemicalBook CAS DataBase List 2,7-DIMETHOXY-QUINOLINE-3-CARBALDEHYDE

2,7-DIMETHOXY-QUINOLINE-3-CARBALDEHYDE synthesis

5synthesis methods

Product Name:2,7-DIMETHOXY-QUINOLINE-3-CARBALDEHYDE
CAS Number:95395-23-6
Molecular formula:C12H11NO3
Molecular Weight:217.22

67-56-1 Synthesis

67-56-1
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$9.00/25ml

2-CHLORO-7-METHOXY-QUINOLINE-3-CARBALDEHYDE

68236-20-4
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$49.00/1g

95395-23-6
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$65.00/100mg

Yield:95395-23-6 95%

Reaction Conditions:

with sodium hydroxide for 2 h;Reflux;

Steps:

2,7-dimethoxyquinoline-3-carbaldehyde 1:

To a solution of 2-chloro-7-methoxyquinoline-3-carbaldehyde (0.23 g, 1.04 mmol, 1eq) in methanol (6 mL) was added sodium hydroxide (0.20 g,5 mmol, 4.8 eq). The reaction mixture was refluxed for 2 h. Theresulting solution is poured into ice. The precipitate was filtered crystallized from methanol to give a yellow powder. Yield: 95%; m.p 160 C; NMR 1H d (ppm) (300 MHz, CDCl3): 10.35 (s, 1H, CHO),8.45 (s, 1H, H4), 7.68 (d, 1H, H5), 7.18 (d, 1H, H8), 7.0 (d, 1H, H6), 4.10(s, 3H, 2-OCH3), 3.90 (s, 3H, 7-OCH3).

References:

Belferdi, Fatiha;Merabet, Naima;Belkhiri, Lotfi;Douara, Bachir [Journal of Molecular Structure,2016,vol. 1118,p. 10 - 17]