2-ACETYL-3-METHYL-BUTYRIC ACID METHYL ESTER synthesis
- Product Name:2-ACETYL-3-METHYL-BUTYRIC ACID METHYL ESTER
- CAS Number:51756-10-6
- Molecular formula:C8H14O3
- Molecular Weight:158.2
67-56-1
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Yield:51756-10-6 81.3%
Reaction Conditions:
at 20;
Steps:
1.a
Sodium methoxide (7.06 g, 0.130 mol) was added portionwise to a solution of 2-acetyl-3-methyl-butyιc acid ethyl ester (15.0 g, 0.0871 mol) in dry MeOH (300 ml_). The reaction mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure and the residue was treated with EtOAc (200 ml_) and H2O (200 mL). The organic residue was separated, dried over MgSO4 and concentrated in vacuum to yield yellow oil (11.2g; 81.3% according to 1H NMR and MS) that was used in the next step without purification.[0093] 1H NMR (CDCI3): δ 3.65 (s, 3H), 3.13 (d, 1 H, J = 9.6), 2.37 (m, 1H), 2.16 (s, 3H), 0.88 (dd, 6H, J = 6.59, J = 11.11 ).
References:
WO2006/66070,2006,A2 Location in patent:Page/Page column 14; 15
