ChemicalBook CAS DataBase List 2-ACETYL-6-METHOXYPYRIDINE 97

2-ACETYL-6-METHOXYPYRIDINE 97 synthesis

5synthesis methods

Product Name:2-ACETYL-6-METHOXYPYRIDINE 97
CAS Number:21190-93-2
Molecular formula:C8H9NO2
Molecular Weight:151.16

1628-89-3
328 suppliers
$17.96/25g

75-36-5 Synthesis

75-36-5
561 suppliers
$17.92/100G

21190-93-2
102 suppliers
$32.00/250mg

Yield: 94%

Reaction Conditions:

with cetyltrimethylammonim bromide;cetyltrimethylammonium chloride in 1,2-dichloro-ethane at 70; for 0.0833333 h;Microwave irradiation;Micellar solution;Friedel-Crafts Acylation;

Steps:

General procedure for microwave-assisted synthesis
General procedure: The mixture of anisole(1c, 0.216 mg, 2 mmol) and acetyl chloride (2a, 0.157 mg, 2 mmol) was treated with CTAB/CTAC, (0.001 mol), in dichloroethane and the resulting reaction mixture was heated in a controlled microwave synthesizer (BiotageInitiator+SP Wave model (0.200W at 2.45 GHz, capped at 60W duringsteady state) for 5 min (attains temperature 100 C and 2 bar pressure). The final product (3o) was isolated by absorbing the reaction mixture into silica geland purifying it by column chromatography using ethyl acetate-petroleumether as the eluent.

References:

Rajendar Reddy;Rajanna;Uppalaiah [Tetrahedron Letters,2013,vol. 54,# 26,p. 3431 - 3436]