2-(ALLYLAMINO)THIAZOLO[4,5-B]PYRIDINE-5,7-DIOL synthesis
- Product Name:2-(ALLYLAMINO)THIAZOLO[4,5-B]PYRIDINE-5,7-DIOL
- CAS Number:70604-10-3
- Molecular formula:C9H9N3O2S
- Molecular Weight:223.25
420-04-2
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70604-10-3
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Yield:70604-10-3 73%
Reaction Conditions:
Stage #1: CYANAMID;N-allyl isothiocyanatewith potassium hydroxide in ethanol at 20; for 1 h;
Stage #2: ethyl (2-chloroaceto)acetatewith potassium hydroxide in ethanol; for 0.5 h;Reflux;
Stage #3: with hydrogenchloride in ethanol;water at 20; pH=7;regioselective reaction;
References:
Shestopalov, Anatoliy M.;Rodinovskaya, Liudmila A.;Shestopalov, Alexander A. [Tetrahedron,2010,vol. 66,# 46,p. 8945 - 8948] Location in patent:supporting information; experimental part