2-AMINO-1-(2-BROMOPHENYL)ETHANOL synthesis

6synthesis methods

Product Name:2-AMINO-1-(2-BROMOPHENYL)ETHANOL
CAS Number:71095-20-0
Molecular formula:C8H10BrNO
Molecular Weight:216.08

Benzeneacetonitrile, 2-bromo-α-[(trimethylsilyl)oxy]-

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71095-20-0
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Yield:71095-20-0 120 g

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at 20;Cooling with ice;

Steps:

2.2 Step 2:

To a suspension of 2-(2-bromophenyl)-2-((trimethylsilyl)oxy)acetonitrile (Step 1, 283 g, 1.0 mol) in THF (1000 mL) was added LAH (1M, 1200 mL) under ice-salt bath. The reaction was stirred at RT overnight and quenched with Na2SO4·10H2O. Filtered and concentrated to give a residue which was purified by column chromatography (silica gel, DCM:MeOH=10:1, Rf=0.4) to give 2-amino-1-(2-bromophenyl)ethan-1-ol (120 g 55%) as a yellow solid.

References:

WO2023/4376,2023,A1 Location in patent:Paragraph 0214-0215