ChemicalBook CAS DataBase List 2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline

2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline synthesis

11synthesis methods

Product Name:2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline
CAS Number:77094-11-2
Molecular formula:C12H12N4
Molecular Weight:212.25

Heterocyclic amines are formed by condensation of creatinine with amino acids during heating or cooking of meat (beef, pork, chicken, and fish). They have also been detected in processed food flavorings, beer, wine, and cigarette smoke. 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) and related heterocyclic amines are produced in small quantities for research purposes. Exposure to MeIQ and related heterocyclic amines occurs primarily through the consumption of cooked meats.Concentrations of heterocyclic amines in meats varied under different cooking conditions (375). The highest concentrations of MeIQ were detected in grilled fish, which appear to be the major dietary source of heterocyclic amines in Japanese. U.S. surveys of dietary intakes of heterocyclic amines in cooked foods have also been reported. Occupational exposure to heterocyclic amines may occur by inhalation of aerosolized particles formed during the cooking process.

537-92-8
117 suppliers
$10.00/1g

2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline

77094-11-2
45 suppliers
$96.00/2 mg

Yield:-

Steps:

Multi-step reaction with 7 steps
1: 75 percent / HNO₃, conc. H₂SO₄ / 0.5 h / 0 °C
2: 1.) H₂SO₄, arsenic acid; 2.) H₂ / 2.) 10percent Pd-C / 1.) 130 deg C, 18 h; 2.) EtOH, 7 d
3: 90 percent / (CH₃CO)2O / 2 h / Ambient temperature
4: 90 percent / LiAlH₄ / tetrahydrofuran / 0 °C
5: 68 percent / HNO₃, H₂SO₄ / 1 h / 0 °C
6: 80 percent / SnCl₂, HCl / 1 h / 100 °C
7: ethanol / 2 h