2-Amino-3-bromo-5-methylpyrazine synthesis
- Product Name:2-Amino-3-bromo-5-methylpyrazine
- CAS Number:74290-65-6
- Molecular formula:C5H6BrN3
- Molecular Weight:188.03
5521-58-4
216 suppliers
$14.00/250mg
74290-65-6
116 suppliers
$25.00/100mg
Yield:74290-65-6 88%
Reaction Conditions:
with pyridine;bromine in dichloromethane at 20;
Steps:
43.1 Step 1: 3-bromo-5-methylpyrazine-2-amine
To a solution of 5-methylpyrazin-2-amine (5.00g, 45.8 mmol) and pyridine (4.35g,55.0 mmol) in DCM (250 mL) was added bromine (8.80 g, 55.0 mmol). The mixture was stirredat rt overnight. To the reaction mixture was added water (150 mL), and the resulting mixture waspartitioned. The organic layer was washed with saturated brine (100 mL), dried over anhydroussodium sulfate and filtered. The filtrate was concentrated in vacuo to give the title compound asa yellow solid (7.64 g, 88 %).MS (ESI, pos. ion) m/z: 190.2 [M+Ht;1H NMR (400 MHz, CDCh) 8 (ppm): 7.83 (s, lH), 4.93 (s, 2H), 2.41 (s, 3H).
References:
SUNSHINE LAKE PHARMA CO., LTD.;TANG, Changhua;REN, Qingyun;YIN, Junjun;YI, Kai;LEI, Yibo;WANG, Yejun;ZHANG, Yingjun WO2018/108125, 2018, A1 Location in patent:Paragraph 00511
5521-58-4
216 suppliers
$14.00/250mg
74290-65-6
116 suppliers
$25.00/100mg
74290-68-9
54 suppliers
$73.00/100mg