2-Amino-3-hydroxy-5-chloropyridine synthesis
- Product Name:2-Amino-3-hydroxy-5-chloropyridine
- CAS Number:40966-87-8
- Molecular formula:C5H5ClN2O
- Molecular Weight:144.56
![6-Chlorooxazolo[4,5-b]pyridin-2(3H)-one](/CAS2/GIF/35570-68-4.gif)
35570-68-4
95 suppliers
$185.00/250mg
40966-87-8
97 suppliers
$18.00/1g
Yield:40966-87-8 80%
Reaction Conditions:
with sodium hydroxide at 130; for 16 h;
Steps:
2-Amino-5-chloropyridin-3-ol
A suspension of 6-chlorooxazolo[4,5-b]pyridin-2(3H)-one (6.Og, 35.3mmol) in 10% NaOH solution (200mL) was stirred at 130 00 for 16h. TLC showed the reaction to be complete. The reaction mixture was cooled to rt , neutralized with 6.0 N HCI and extracted with EtOAc (3x200mL). The organic layer was washed with brine (200mL), dried (Na2SO4), filtered and concentrated under reduced pressure to afford 2-amino-5-chloropyridin-3-ol as a brown solid. Yield: 4.Og (80%); 1H NMR (400 MHz, DMSO-d6): 10.03 (bs, 1H), 7.41 (d, J= 2.1 Hz, 1H), 6.82 (d, J= 2.1 Hz, 1H), 5.68 (bs, 2H); MS (ESl+) for CHNOS m/z 145.13 [M+H].
References:
WO2018/37223,2018,A1 Location in patent:Page/Page column 222; 223
16867-03-1
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$10.00/25g
40966-87-8
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$18.00/1g
![2,3-Dihydropyrido[2,3-d][1,3]oxazol-2-one](/CAS/GIF/60832-72-6.gif)
60832-72-6
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$5.00/1g
40966-87-8
97 suppliers
$18.00/1g
874-24-8
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$14.14/1gm:
40966-87-8
97 suppliers
$18.00/1g