2-AMINO-3-(METHYLAMINO)PYRAZINE synthesis
- Product Name:2-AMINO-3-(METHYLAMINO)PYRAZINE
- CAS Number:84996-40-7
- Molecular formula:C5H8N4
- Molecular Weight:124.14
6863-73-6
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$10.00/5g
74-89-5
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$13.44/25ML
84996-40-7
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$65.00/100mg
Yield:84996-40-7 80%
Reaction Conditions:
with copper(II) sulfate in water at 120; for 3 h;Microwave irradiation;
Steps:
1.41 5.1.41 N-Methylpyrazine-2,3-diamine (26)
A mixture of 25 (5.20 g, 40.1 mmol) and CuSO4 (640 mg, 4.01 mmol) in 12 M methanamine aqueous solution (40.0 mL, 480 mmol) was stirred at 120 °C for 3 h under microwave irradiation. The reaction mixture was allowed to cool to room temperature and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, 0-5% MeOH in CHCl3) to give 26 (3.99 g, 80%) as a yellow solid. 1H NMR (DMSO-d6) δ 2.81 (d, 3H, J = 4.7 Hz), 5.84 (s, 2H), 6.13 (q, 1H, J = 4.7 Hz), 7.09 (d, 1H, J = 3.1 Hz), 7.23 (d, 1H, J = 3.1 Hz); MS (ESI) m/z 125 [M+H]+.
References:
Chino, Ayaka;Masuda, Naoyuki;Amano, Yasushi;Honbou, Kazuya;Mihara, Takuma;Yamazaki, Mayako;Tomishima, Masaki [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 13,p. 3515 - 3526]
21943-12-4
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74-89-5
7 suppliers
$13.44/25ML
84996-40-7
58 suppliers
$65.00/100mg