2-AMINO-3-PHENYLPROPIONITRILE HYDROCHLORIDE synthesis

5synthesis methods

Product Name:2-AMINO-3-PHENYLPROPIONITRILE HYDROCHLORIDE
CAS Number:93554-83-7
Molecular formula:C9H11ClN2
Molecular Weight:182.65

143-33-9 Synthesis

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2-AMINO-3-PHENYLPROPIONITRILE HYDROCHLORIDE

93554-83-7
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Yield:93554-83-7 80%

Reaction Conditions:

Stage #1:sodium cyanide with ammonia in water at 25; under 1125.11 Torr; for 0.5 h;
Stage #2:phenylacetaldehyde with acetic acid in water at 35; for 4.75 h;
Stage #3: with hydrogenchloride in 1,4-dioxane;diethyl ether

Steps:

1
Example 1: Strecker synthesis of rac-2-amino-3-phenylpropionitrile A 30 wt% solution of sodium cyanide (653 g, 4.0 mol) at 25§C was saturated with ammonia gas at 0.15 MPa In 30 min time 240 g (4.0 mol) of acetic acid was added, followed by the addition of 534 g (4.0 mol) of phenylacetaldehyde (80-90%) in 45 min. After stirring for 4 h at 35§C, the reaction mixture was extracted with 2 L of CH₂Cl₂. The organic layer was evaporated and the residue dissolved in 4.5 L of diethyl ether. To this solution 3-3.5 mol of saturated HCI in dioxan was added. The precipitated rac-2-amino-3-phenylpropionitrile.HCI was filtered and washed with ether (yield 80-85%).

References:

DSM IP Assets B.V. EP1352894, 2003, A1 Location in patent:Page/Page column 4

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