2-amino-4-(4-fluorophenyl)thiazole-5-carbonitrile synthesis
2synthesis methods
- Product Name:2-amino-4-(4-fluorophenyl)thiazole-5-carbonitrile
- CAS Number:952753-59-2
- Molecular formula:C10H6FN3S
- Molecular Weight:219.24
Yield:952753-59-2 73%
Reaction Conditions:
Stage #1: 3-(4-fluorophenyl)-3-oxopropionitrilewith pyridine in ethanol at 70; for 0.25 h;
Stage #2: thioureawith iodine in ethanol at 20; for 1 h;
References:
Deng, Xiaoyun;Salgado-Polo, Fernando;Shao, Tuo;Xiao, Zhiwei;Van, Richard;Chen, Jiahui;Rong, Jian;Haider, Ahmed;Shao, Yihan;Josephson, Lee;Perrakis, Anastassis;Liang, Steven H. [Journal of Medicinal Chemistry,2021,vol. 64,# 20,p. 15053 - 15068]