2-AMINO-4-METHYL-1,3-THIAZOLE-5-CARBOHYDRAZIDE synthesis

Yield:-

Reaction Conditions:

with hydrazine hydrate in ethanol at 20; for 3 h;

Steps:

5.2. General procedure for preparation of 8a-d

General procedure: A mixture of substituted ethyl benzoate 2 (10 mmol) and hydrazinehydrate (20 mmol) in ethanol was stirred at room temperaturefor 3 h and then filtered. The crude product recrystallizedfrom absolute alcohol to give 3a-l, which were used directly forthe next step. Under this same condition, the intermediate compounds8a-d were also prepared.

References:

He, Haifeng;Wang, Wei;Zhou, Yuan;Xia, Qin;Ren, Yanliang;Feng, Jiangtao;Peng, Hao;He, Hongwu;Feng, Lingling [Bioorganic and Medicinal Chemistry,2016,vol. 24,# 8,p. 1879 - 1888]