ChemicalBook CAS DataBase List 2-AMINO-4-(P-TOLYL)THIAZOLE

2-AMINO-4-(P-TOLYL)THIAZOLE synthesis

13synthesis methods

Product Name:2-AMINO-4-(P-TOLYL)THIAZOLE
CAS Number:2103-91-5
Molecular formula:C10H10N2S
Molecular Weight:190.26

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619-41-0 Synthesis

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Yield: 99%

Reaction Conditions:

in ethanol for 1 h;Reflux;

Steps:

4-(p-Tolyl)thiazol-2-amine. A mixture of 2-bromo-1-(p-tolyl)ethanone (5.00 g, 23.5 mmol) and thiourea (1.97 g, 25.9 mmol) in 95% EtOH (33.5 mL) was heated at reflux for 60 min. The solution was concentrated and added with water (50 mL) and saturated aqueous Na₂CO₃(1.0 mL). The resultant precipitate was filtered and washed with hot water. The solids were filtered and dried under vacuum to give 4-(p-tolyl)thiazol-2-amine (4.40 g) as white solids in 99% yield: ¹H NMR (500 MHz, CDCl₃) δ 7.66 (d, J=8.0 Hz, 2H), 7.18 (d, J=7.5 Hz, 2H), 6.66 (s, 1H), 5.25 (bs, 2H), 2.36 (s, 6H).

References:

Lau, Johnson;Huang, Jiann-Jyh US2011/230486, 2011, A1 Location in patent:Page/Page column 9