2-aMino-5-(benzyloxy)pyriMidin-4(3H)-one synthesis
4synthesis methods
- Product Name:2-aMino-5-(benzyloxy)pyriMidin-4(3H)-one
- CAS Number:93534-87-3
- Molecular formula:C11H11N3O2
- Molecular Weight:217.22
Yield:93534-87-3 160 g
Reaction Conditions:
Stage #1: guanidine carbonatewith sodium ethanolate in ethanol at 20; for 1 h;
Stage #2: 2-benzyloxy-3-oxo-propionic acid ethyl ester in tetrahydrofuran;ethanol; for 15 h;Reflux;
References:
McGowan, David;Herschke, Florence;Pauwels, Frederik;Stoops, Bart;Last, Stefaan;Pieters, Serge;Scholliers, Annick;Thoné, Tine;Van Schoubroeck, Bertrand;De Pooter, Dorien;Mostmans, Wendy;Khamlichi, Mourad Daoubi;Embrechts, Werner;Dhuyvetter, Deborah;Smyej, Ilham;Arnoult, Eric;Demin, Samu?l;Borghys, Herman;Fanning, Gregory;Vlach, Jaromir;Raboisson, Pierre [Journal of Medicinal Chemistry,2016,vol. 59,# 17,p. 7936 - 7949] Location in patent:supporting information