2-Amino-5-bromo-3-fluorophenol synthesis

9synthesis methods

Product Name:2-Amino-5-bromo-3-fluorophenol
CAS Number:186309-73-9
Molecular formula:C6H5BrFNO
Molecular Weight:206.01

Benzenamine, 4-bromo-2-fluoro-6-methoxy-, hydrobromide (1:1)

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186309-73-9
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Yield:186309-73-9 92%

Reaction Conditions:

with boron tribromide in dichloromethane at 0 - 20; for 2 h;

Steps:

33 2-Amino-5-bromo-3-fluorophenol

To a suspension of 4-bromo-2-fluoro-6-methoxyaniline hydrobromide (1 equiv) in DCM (0.3 M) was added boron tribromide (2 equiv) in DCM at 0° C. The reaction mixture was stirred at room temperature for 2 h. After quenching, the reaction mixture was diluted with DCM then purified by silica gel chromatography (0 to 100% ethyl acetate in hexane) to give the title compound (92% yield). MS (ESI) m/z 205.9 [M+H]⁺.

References:

US2014/200206,2014,A1 Location in patent:Paragraph 0400

1261216-27-6 Synthesis