ChemicalBook CAS DataBase List 2-AMINO-5-BROMOBENZOPHENONE

2-AMINO-5-BROMOBENZOPHENONE synthesis

13synthesis methods

Product Name:2-AMINO-5-BROMOBENZOPHENONE
CAS Number:39859-36-4
Molecular formula:C13H10BrNO
Molecular Weight:276.13

2-Amino-5-bromobenzophenone is a benzophenone (B204980) derivative that is widely used in the synthesis of pharmaceutical compounds. It was prepared from 2-aminobenzonitrile sodium arylsulfinate, Pd(OAc)2 , bpy, and p-NBSA by stirring in a 2:1 mixture of THF/H2O for 48 h at 80℃.

39263-32-6
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$15.00/1g

873-55-2 Synthesis

873-55-2
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39859-36-4
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$9.00/250mg

Yield: 90%

Reaction Conditions:

with p-nitrobenzenesulfonic acid;palladium diacetate in tetrahydrofuran;water at 80; for 48 h;Inert atmosphere;Schlenk technique;

Steps:

General Procedure for the Synthesis of o-Aminobenzophenones
General procedure: Under a N₂ atmosphere, a Schlenk tube was charged with 2-aminobenzonitrile 1 (0.3 mmol),sodium arylsulfinate 2 (0.6 mmol), Pd(OAc)₂ (10 mol %), bpy (20 mol %), p-NBSA (10 equiv), THF (2 mL), and H₂O (1 mL) at room temperature. The reaction mixture was stirred vigorously at 80 °C for 48 h. The mixture was poured into ethyl acetate, which was washed with saturated NaHCO₃ (2 × 10 mL) and then brine (1 × 10 mL). After the aqueous layer was extracted with ethyl acetate, the combined organic layers were dried over anhydrous MgSO₄ and evaporated under reduced pressure. The residue was purified by flash column chromatography (hexane/ethyl acetate) to afford the desired products 3.

References:

Chen, Jiuxi;Li, Jianjun;Su, Weike [Molecules,2014,vol. 19,# 5,p. 6439 - 6449]

2835-77-0 Synthesis