2-amino-5-(trifluoromethyl)pyridine-3-carbonitrile synthesis
- Product Name:2-amino-5-(trifluoromethyl)pyridine-3-carbonitrile
- CAS Number:1211514-97-4
- Molecular formula:C7H4F3N3
- Molecular Weight:187.12
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Yield:1211514-97-4 3.65 g
Reaction Conditions:
with 1,1'-bis-(diphenylphosphino)ferrocene;tris-(dibenzylideneacetone)dipalladium(0) in N,N-dimethyl-formamide at 120; for 0.5 h;
Steps:
17.1 Production Example 17 (1)
Production Example 17 (1) [0787] A mixture of 5.22 g of 2-amino-3-bromo-5-trifluoromethylpyridine, 3.80 g of zinc cyanide, 600 mg of tris(dibenzylideneacetone)dipalladium(O), 720 g of 1,1'-bis (diphenylphosphino) ferrocene and 20 ml of DMF was stirred at 120°C for 30 minutes. Ethyl acetate and water were added to the cooled reaction mixture, and the mixture was filtered. The aqueous layer of the filtrate was extracted with ethyl acetate, then combined with the organic layer of the filtrate and washed with water, and dried over anhydrous magnesium sulfate. The mixture was concentrated under reduced pressure, and then the resulting residue was applied to a silica gel column chromatography to obtain 3.65 g of 2-amino-3-cyano-5-trifluoromethylpyridinepyridine. 2-Amino-3-cyano-5-trifluoromethylpyridinepyridine 1H-NMR (CDCl3) δ: 8.50(1H, d), 7.93(1H, d), 5.60(2H, brs)
References:
EP2865671,2015,A1 Location in patent:Paragraph 0787
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