2-amino-5-trimethylsilanylethynylpyridine synthesis
- Product Name:2-amino-5-trimethylsilanylethynylpyridine
- CAS Number:457628-40-9
- Molecular formula:C10H14N2Si
- Molecular Weight:190.32
20511-12-0
457 suppliers
$6.00/1g
1066-54-2
470 suppliers
$9.00/10g
457628-40-9
15 suppliers
inquiry
Yield:457628-40-9 95%
Reaction Conditions:
with bis-triphenylphosphine-palladium(II) chloride;copper(l) iodide;triethylamine in N,N-dimethyl-formamide at 20; for 1 h;Inert atmosphere;
Steps:
44
The mixture of 2-amino-5-iodopyridine (1 g, 4.52 mmol, 1.0 eq.) and CuI (0.08 g, 0.41 mmol, 0.09 eq.) was dispersed in 50 ml of N,N-dimethylformamide. In under nitrogen atmosphere, were addedbis(triphenylphosphine) palladium dichloride (0.3 g, 0.41 mmol, 0.09 eq.), triethylamine (2 ml, 14.3 mmol, 3.0 eq) and trimethylsilylacetylene (1.34 ml, 9.6 mmol, 2.1 when volume), stirred at room temperature for 1 hour. Extracted with ethyl acetate, the organic phase was washed with saturated brine, no over anhydrous sodium sulfate, and dried under reduced pressure to spin. Finally, to give a brown solid was purified by silica gel column 5-(trimethylsilylethynyl)-2-aminopyridine (867 mg, yield: 95%).
References:
CN105622638,2016,A Location in patent:Paragraph 0369
![Pyridine, 2-nitro-5-[2-(trimethylsilyl)ethynyl]-](/CAS/20210305/GIF/936342-51-7.gif)
936342-51-7
0 suppliers
inquiry
457628-40-9
15 suppliers
inquiry