2-amino-9H-thioxanthen-9-one synthesis

9synthesis methods

Product Name:2-amino-9H-thioxanthen-9-one
CAS Number:33923-98-7
Molecular formula:C13H9NOS
Molecular Weight:227.29

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Yield:-

Reaction Conditions:

with iron;ammonium chloride in ethanol;

Steps:

The syntheses of 2-methylaminothioxanthones 13 and 14 (eq 2 and Scheme 4) started with the corresponding known 2-nitro compounds 18¹⁰and 19¹³, which were prepared by literature methods. The 2-nitro substituent was reduced to the amines 20 and 21 by iron,¹⁰followed by acylation. The resultant carboxamides 22 and 23 were then alkylated to introduce the N-methyl substituents 24, 25. Subsequent base hydrolysis of the acetamides furnished the thioxanthone 2-methylamines 13 and 14.

References:

US2013/231484,2013,A1 Location in patent:Paragraph 0046

86-39-5 Synthesis