ChemicalBook CAS DataBase List 2-AMINO-N-CYCLOHEXYLBENZAMIDE

2-AMINO-N-CYCLOHEXYLBENZAMIDE synthesis

9synthesis methods

Product Name:2-AMINO-N-CYCLOHEXYLBENZAMIDE
CAS Number:56814-11-0
Molecular formula:C13H18N2O
Molecular Weight:218.29

612-25-9 Synthesis

612-25-9
308 suppliers
$6.00/5g

108-91-8 Synthesis

108-91-8
583 suppliers
$10.00/5mL

56814-11-0
45 suppliers
$15.00/250mg

Yield: 82%

Reaction Conditions:

with caesium carbonate at 110; for 16 h;Schlenk technique;Inert atmosphere;

Steps:

5 Example 5
In the schlenk tube was added 0.5 mmol o-nitrobenzyl alcohol,0.5 ml of cyclohexylamine,0.25 mmol of cesium carbonate, charged with N2 protection, the reaction was stirred at 110 ° C for 16 hours,Stop heating and stirring, cooled to room temperature,The reaction solution was diluted with 5 mL of ethyl acetate, filtered under atmospheric pressure, and the resulting filtrate was dried under reduced pressure,The crude product was obtained and purified by column chromatography (silica gel) to give the title product,The column eluate used was a volume of 8: 1 petroleum ether:Ethyl acetate mixed solvent, yield 72%.

References:

South China University of Technology;Zhang Min;Zhang Shudi;Tan Zhenda CN107353217, 2017, A Location in patent:Paragraph 0085; 0086; 0087; 0088; 0089; 0090; 0091-0093

118-48-9 Synthesis