2-(aminomethyl)-4-(trifluoromethyl)aniline synthesis

Yield:765297-88-9 60%

Reaction Conditions:

with ammonium hydroxide;hydrogen under 2068.65 Torr;

References:

Lu, Zhijian;Napolitano, Joann B.;Theberge, Ashleigh;Ali, Amjad;Hammond, Milton L.;Tan, Eugene;Tong, Xinchun;Xu, Suoyu S.;Latham, Melanie J.;Peterson, Laurence B.;Anderson, Matt S.;Eveland, Suzanne S.;Guo, Qiu;Hyland, Sheryl A.;Milot, Denise P.;Chen, Ying;Sparrow, Carl P.;Wright, Samuel D.;Sinclair, Peter J. [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 24,p. 7469 - 7472] Location in patent:scheme or table