![](/CAS/GIF/91-02-1.gif)
2-Benzoylpyridine synthesis
- Product Name:2-Benzoylpyridine
- CAS Number:91-02-1
- Molecular formula:C12H9NO
- Molecular Weight:183.21
Yield:91-02-1 85%
Reaction Conditions:
with dipotassium peroxodisulfate in water at 120; for 18 h;Green chemistry;regioselective reaction;
Steps:
General procedure for 2-acylation of pyridines
General procedure: A 10 mL microvawe vial was charged with pyridine derivatives (1 equiv, 1 mmol), alcohol derivatives (2 equiv, 2 mmol), K2S2O8 (2 mmol, 540 mg) and water (H2O, 2 mL). The vial was then sealed and immersed in an oil bath, which was preheated at 120°C, for 18 h. After this time the reaction mixture was then cooled to room temperature and diluted with water (3 mL) and the aqueous phase was extracted with dichloromethane (2 x 5 mL). The organic extracts were dried over sodium sulfate and filtered. Concentration of the solution by rotary evaporation under reduced pressure gave a residue which was purified by using column chromatography (n-hexane/EtOAc, 4/1) to yield the desired products.
References:
Kianmehr, Ebrahim;Pakbaznia, Azin;Faghih, Nasser;Foroumadi, Alireza [Tetrahedron,2017,vol. 73,# 11,p. 1407 - 1412]
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