(2-BENZYL-1H-BENZIMIDAZOL-1-YL)ACETIC ACID synthesis
- Product Name:(2-BENZYL-1H-BENZIMIDAZOL-1-YL)ACETIC ACID
- CAS Number:152342-26-2
- Molecular formula:C16H14N2O2
- Molecular Weight:266.29
667408-26-6
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152342-26-2
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Yield:152342-26-2 95%
Reaction Conditions:
with sodium hydroxide in methanol at 20;Inert atmosphere;
Steps:
Representative procedure for the preparation of 2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetic acid (9a)
General procedure: To a stirred solution of methyl 2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetate 8a (200 mg, 0.75 mmol) in MeOH (2 mL) was added 1 N NaOH solution (2.25 mL, 2.25 mmol) dropwise. After stirring at room temperature for 30 min, 1 N HCl solution was added dropwise to acidify to pH 3. The reaction mixture was extracted with EtOAc (3 ~ 50 mL) and washed with H2O (~ 30 mL). The organic layer was dried over anhydrous MgSO4, and concentrated in vacuo to yield the title product 9a (150 mg, 80%).
References:
Kim, TaeHun;Yang, Ha Yun;Park, Beoung Gun;Jung, Seo Yun;Park, Jong-Hyun;Park, Ki Duk;Min, Sun-Joon;Tae, Jinsung;Yang, Hyejin;Cho, Suengmok;Cho, Sung Jin;Song, Hyundong;Mook-Jung, Inhee;Lee, Jiyoun;Pae, Ae Nim [European Journal of Medicinal Chemistry,2017,vol. 125,p. 1172 - 1192] Location in patent:supporting information
621-72-7
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152342-26-2
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329937-74-8
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152342-26-2
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103-80-0
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152342-26-2
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615-43-0
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152342-26-2
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