2-Benzyloxy-3-nitro-benzoic Acid Benzyl Ester synthesis

Yield:217095-89-1 67%

Reaction Conditions:

Stage #1: 3-nitrosalicylic acidwith potassium carbonate in N,N-dimethyl-formamide at 20; for 0.0833333 h;
Stage #2: benzyl bromide in N,N-dimethyl-formamide at 70; for 39 h;

References:

Rooney, Timothy P. C.;Filippakopoulos, Panagis;Fedorov, Oleg;Picaud, Sarah;Cortopassi, Wilian A.;Hay, Duncan A.;Martin, Sarah;Tumber, Anthony;Rogers, Catherine M.;Philpott, Martin;Wang, Minghua;Thompson, Amber L.;Heightman, Tom D.;Pryde, David C.;Cook, Andrew;Paton, Robert S.;Mueller, Susanne;Knapp, Stefan;Brennan, Paul E.;Conway, Stuart J. [Angewandte Chemie - International Edition,2014,vol. 53,# 24,p. 6126 - 6130][Angew. Chem.,2014,vol. 53,# 24,p. 6126 - 6130,5] Location in patent:supporting information