2-(BOC-AMINO)-CYCLOPENTANEMETHANAMINE synthesis

Yield:860297-27-4 99%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in ethanol;

Steps:

21.a

) Tert-butyl [ (lS, 2R)-2- (aminomethyl) cyclopentyl] carbamate; tert-butyl [(lS, 2R)-2-(azidomethyl) cyclopentyl] carbamate (0.070g, 0.291 mmol) and 10% Pd on activated carbon (12 mg) in EtOH (5 mL) was thoroughly degassed, and then stirred under an atmosphere of H2 over night. The mixture was filtered through Celite and concentrated to give 0.062 g (99%) of the title compound. 'H NMR (400 MHz, MeOH-d4) 8 3.55-3. 49 (m, 1H), 2. 72 (dd, J= 12. 6,5. 7 Hz, 1H), 2.54 (dd, J= 12.6, 7.3 Hz, 1H), 1.99-1. 25 (m, 16H) ; 13C NMR (101 MHz, MeOH-d4) 6 158.2, 79.8, 56.4, 50.07, 45.8, 33.6, 29.5, 28.8, 23.2.

References:

WO2005/66132,2005,A1 Location in patent:Page/Page column 64