Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 2-BROMO-1-(5-BROMO-2-METHOXYPHENYL)ETHANONE
67639-58-1

2-BROMO-1-(5-BROMO-2-METHOXYPHENYL)ETHANONE synthesis

4synthesis methods
-

Yield:67639-58-1 78%

Reaction Conditions:

with N-Bromosuccinimide;toluene-4-sulfonic acid in neat (no solvent) at 60; for 0.25 h;regioselective reaction;

Steps:

General procedure for the synthesis of phenacyl bromides (3a-i)

General procedure: The round-bottom flask containing acetophenone derivative 2a-i (4 mmol) and PTSA (0.076 g, 0.4 mmol) was heated to 60 oC to turn the reaction mixture into a paste and then NBS (0.854 g, 4.8 mmol) was added slowly. After 15 min., the reaction mixture was cooled to room temperature and water (20 ml) was added. The crude product was extracted with dichloromethane (2 x 20 mL), dried over anhydrous Na2SO4 and puried by crystallization from hexane-dichloromethane to give pure product.

References:

Phan, Phuong-Thuy T.;Nguyen, Hong-Nhung T.;Kim, Son N.;Pham, Tuan-Anh N. [Synthetic Communications,2021,vol. 51,# 5,p. 786 - 796] Location in patent:supporting information