2-Bromo-2,2-difluoroacetamide synthesis

Yield: 100%

Reaction Conditions:

with ammonium hydroxide in diethyl ether at 20; for 3 h;Cooling with ice;

Steps:

2 [Manufacturing of bromodifluoroacetamide]
187.1 g of ethyl bromodifluoroacetate was placed in a 500 mL Ellenmeier flask, 150 mL of diethyl ether was added to dissolve the flask, and 100.5 g of a 28% aqueous ammonia solution was added while cooling with ice.After stirring the solution at room temperature for 3 hours, the reaction solution was concentrated to 60 ° C.After vacuum drying for 2 hours, followed by washing 3 times with 30 mL of hexane,Vacuum drying was performed again at 60 ° C. for 3 hours to obtain 160.4 g (yield 100%) of bromodifluoroacetamide.

References:

Nippon Synthetic Chemical Industry Co Ltd;Aoki, Yasuhiro;Tatsumi, Ryouta;Maeda, Seiji;Hayakawa, Seiichiro JP5832370, 2015, B2 Location in patent:Paragraph 0060-0061