2-Bromo-2',4'-difluoroacetophenone synthesis
- Product Name:2-Bromo-2',4'-difluoroacetophenone
- CAS Number:102429-07-2
- Molecular formula:C8H5BrF2O
- Molecular Weight:235.03
364-83-0
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102429-07-2
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Yield: 97%
Reaction Conditions:
with bromine;acetic acid at 10 - 30; for 6.25 h;
Steps:
40A
Example 40A; 2-Bromo-1-(2, 4-difluorophenyl) ethanone; 5 ml bromine are dropped into a solution of 150 g (961 mmol) 1- (2, 4-difluoro- phenyl) ethanone in 750 ml acetic acid at 10-15°C. After 30 min. , the mixture is warmed up to 30°C until the reaction starts, then cooled again to 15-20°C, and a further 45 ml bromine are added dropwise. The reaction mixture is stirred at rt for 5 hours, then 1 1 ice-water and 400 ml DCM are added. The organic phase is washed three times with water, dried over sodium sulfate, and the solvent is removed in vacuum to yield 220 g (97% of th.) of the title compound. 'H-NMR (200 MHz, CDC13) : 8 = 4.47 (s, 2H), 6.92 (mc, 1H), 7.01 (mc, 1H), 8.00 (mc, 1H).
References:
BAYER AKTIENGESELLSCHAFT WO2003/76405, 2003, A1 Location in patent:Page/Page column 71-72
372-18-9
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598-21-0
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$10.00/10 g
102429-07-2
195 suppliers
$19.00/1g