![](/StructureFile/ChemBookStructure3/GIF/CB2327965.gif)
2-BROMO-2-METHYL-N-(1,3-THIAZOL-2-YL)PROPANAMIDE synthesis
- Product Name:2-BROMO-2-METHYL-N-(1,3-THIAZOL-2-YL)PROPANAMIDE
- CAS Number:301165-22-0
- Molecular formula:C7H9BrN2OS
- Molecular Weight:249.13
Yield:301165-22-0 95%
Reaction Conditions:
with triethylamine in dichloromethane at -5; for 1 h;
Steps:
E1
Preparation of 2-Bromo-2-methyl-N-thiazol-2-yl-propionamide used in Example El is described below. 2-Bromo-2-methyl-N-thiazol-2-yl-propionamide:To a solution of 2-aminothiazole (0.5, 5mmol) and triethyl amine (2.0 ml, 15 mmol) in DCM (10 ml) 2-Bromo-2-methyl-propionyl bromide (0.74 ml, 6 mmol) was added drop wise
References:
WO2008/104994,2008,A2 Location in patent:Page/Page column 46-47