2-bromo-3-(bromomethyl)benzonitrile synthesis
- Product Name:2-bromo-3-(bromomethyl)benzonitrile
- CAS Number:1086429-87-9
- Molecular formula:C8H5Br2N
- Molecular Weight:274.94
263159-64-4
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Yield:1086429-87-9 62%
Reaction Conditions:
with N-Bromosuccinimide;dibenzoyl peroxide in tetrachloromethane;Reflux;
Steps:
Step 3: A mixture of compound 249 (1 1 g, 56.1 mmol), NBS (10 g, 56.1 mmol) and BPO (81 mg, 0.34 mmol) in CCI4 (150 mL) was heated at reflux overnight. TLC (petroleum ether / EtOAc = 5:1 ) showed the reaction was completed. The mixture was filtered and the filtrate was concentrated. The residue was purified by column chromatography over silica gel (petroleum ether / EtOAc = 20:1 ) to yield compound 250 (9.6 g, 62%) as a white solid. 1H NMR (400 MHz, CDCI3) δ 7.69- 7.67 (d, 1 H), 7.63-7.61 (d, 1 H), 7.45-7.41 (t, 1 H), 4.61 (s, 2H)
References:
WO2013/132376,2013,A1 Location in patent:Page/Page column 226-227
53663-39-1
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101421-85-6
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$117.51/Price $/250mgs:
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