![](/CAS/GIF/149947-15-9.gif)
2-BROMO-3-FLUOROBENZALDEHYDE synthesis
- Product Name:2-BROMO-3-FLUOROBENZALDEHYDE
- CAS Number:149947-15-9
- Molecular formula:C7H4BrFO
- Molecular Weight:203.01
![(3-bromo-2-fluorophenyl)methanol](/CAS/GIF/261723-32-4.gif)
261723-32-4
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![2-BROMO-3-FLUOROBENZALDEHYDE](/CAS/GIF/149947-15-9.gif)
149947-15-9
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Yield:149947-15-9 83%
Reaction Conditions:
with manganese(IV) oxide in dichloromethane at 45;
Steps:
21.20.1 Example 21.20
To a solution of (3-bromo-2-fluoro-phenyl)methanol (2.750 g, 13.413 mmol) in dichloromethane (50 mL) was added manganese dioxide (9.32 g, 107.31 mmol) and the resulting mixture was stirred at 45°C overnight. Once complete, the reaction was filtered through diatomaceous earth and washed with dichloromethane to obtain 3-bromo-2-fluoro-benzaldehyde as a white solid (2.24 g, 83%). lU NMR (400 MHz, DMSO-i ) δ 10.19 (dt, = 1.3, 0.7 Hz, 1H), 8.05 (tdd, = 6.8, 3.1, 1.5 Hz, 1H), 7.85 (ddt, = 7.9, 6.4, 1.5 Hz, 1H), 7.37 (tdt, = 7.8, 1.6, 0.8 Hz, 1H).
References:
F. HOFFMANN-LA ROCHE AG;GENENTECH, INC.;YU, Jiang;WU, Guosheng;YUEN, Po-Wai;VILLEMURE, Elisia;SCHWARZ, Jacob;LY, Cuong;SELLERS, Benjamin;VOLGRAF, Matthew WO2015/52226, 2015, A1 Location in patent:Paragraph 0379
![2-Bromofluorobenzene](/CAS/GIF/1072-85-1.gif)
1072-85-1
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![Benzamide, N,N-diethyl-3,4-difluoro-](/CAS/20210305/GIF/130286-84-9.gif)
130286-84-9
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![2-BROMO-3-FLUOROBENZALDEHYDE](/CAS/GIF/149947-15-9.gif)
149947-15-9
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![3-Bromo-2-fluorobenzoic acid](/CAS/GIF/161957-56-8.gif)
161957-56-8
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![2-BROMO-3-FLUOROBENZALDEHYDE](/CAS/GIF/149947-15-9.gif)
149947-15-9
158 suppliers
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![3-Bromo-2-fluorobenzoic acid methyl ester](/CAS/GIF/206551-41-9.gif)
206551-41-9
137 suppliers
$9.00/250mg
![2-BROMO-3-FLUOROBENZALDEHYDE](/CAS/GIF/149947-15-9.gif)
149947-15-9
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![1-Bromo-3-bromomethyl-2-fluorobenzene](/CAS/GIF/149947-16-0.gif)
149947-16-0
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$11.00/250mg
![2-BROMO-3-FLUOROBENZALDEHYDE](/CAS/GIF/149947-15-9.gif)
149947-15-9
158 suppliers
$6.00/1g