2-Bromo-5-chloropyridin-3-ol synthesis
- Product Name:2-Bromo-5-chloropyridin-3-ol
- CAS Number:127561-70-0
- Molecular formula:C5H3BrClNO
- Molecular Weight:208.44
74115-12-1
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$9.00/1g
127561-70-0
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$19.00/100mg
Yield:-
Reaction Conditions:
with bromine in sodium hydroxide
Steps:
60.a (a)
(a) 2-bromo-5-chloro-3-pyridinol A solution of bromine (12.35 g) in 10% NaOH (70 mL) was added dropwise with stirring to a solution of 5-chloro-3-pyridinol (10.00 g) in 10% NaOH (70 mL). After the addition was complete, the reaction was stirred at 22° C. for 20 h. The reaction was cooled to 0° C. and acidified to pH 5.3 with concentrated HCl (aq). The precipitate was filtered and dried under vacuum for 60 h to afford a) (15.66 g, 97%).
References:
Bristol-Myers Squibb Company US4954502, 1990, A