2-Bromo-3-hydroxy-6-iodopyridine synthesis
- Product Name:2-Bromo-3-hydroxy-6-iodopyridine
- CAS Number:129611-32-1
- Molecular formula:C5H3BrINO
- Molecular Weight:299.89
6602-32-0
408 suppliers
$10.00/1g
129611-32-1
73 suppliers
$45.00/100mg
Yield: 97%
Reaction Conditions:
with iodine;potassium carbonate in water at 15;
Steps:
14 Synthesis of compound 701-A2:
To a solution of 701-A1 (2-bromo-pyridin-3-ol, CAS number 6602-32-0, 60 g, 0.35 mol) in H2O (600 mL) wasadded K2CO3 (96.7 g, 0.7 mol), I2 (90.7 g, 0.357 mol). The reaction mixture was stirred at 15 °C for overnight. Themixture was adjusted the pH to 5 with 3N HCl. The resulting solid was collected by filtration, washed with water (200mL3), dried to give 701-A2 (2-bromo-6-iodopyridin-3-ol, 101 g, yield: 97%) as a yellow solid.1H NMR (300 MHz, DMSO-d6) δ 11.11 (s, 1H), 7.62 (d, J = 8.4 Hz, 1H), 7.03 (d, J = 8.1 Hz, 1H).
References:
Kangpu Biopharmaceuticals, Ltd.;LEE, Wen-Cherng;LIAO, Baisong;ZHANG, Lei EP3590924, 2020, A1 Location in patent:Paragraph 0199; 0206-0207
6602-32-0
408 suppliers
$10.00/1g
129611-32-1
73 suppliers
$45.00/100mg
6602-32-0
408 suppliers
$10.00/1g
129611-32-1
73 suppliers
$45.00/100mg
129611-33-2
13 suppliers
$175.00/500mg