2-bromo-3-methoxycyclopent-2-enone synthesis
- Product Name:2-bromo-3-methoxycyclopent-2-enone
- CAS Number:14203-25-9
- Molecular formula:C6H7BrO2
- Molecular Weight:191.02
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Yield:14203-25-9 76%
Reaction Conditions:
with N-Bromosuccinimide in dichloromethane at 25; for 16 h;
Steps:
7.B
Example 7B; 2-bromo-3-methoxycyclopent-2-enone; A mixture of Example 7A (500 mg, 4.46 mmol) and Λ^-bromosuccinimide (794 mg, 4.46 mmol) in dichloromethane (5 mL) was stirred at 25 °C for 16 hours. The mixture was concentrated in vacuo. The residue was purified on a silica column (dichloromethane/methanol = 200:1, v/v) to afford the title compound (650 mg, 3.40 mmol, 76% yield) as a solid. .H NMR (400 MHz, CDC13) δ ppm 4.12 (s, 3H), 2.79-2.82 (m, 2H), 2.62-2.65 (m, 2H); LC/MS (ESI) m/z 191 (M+H)+.
References:
WO2012/83170,2012,A1 Location in patent:Page/Page column 181
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