2-BROMO-3-METHOXYPHENOL synthesis

Yield: 30%

Reaction Conditions:

Stage #1:1-methoxy-3-tetrahydropyran-2-yloxybenzene with n-butyllithium in tetrahydrofuran;hexane at 20; for 2.75 h;
Stage #2: with ethylene dibromide in tetrahydrofuran;hexane at 0 - 20; for 14 h;
Stage #3: with hydrogenchloride in tetrahydrofuran;hexane;water for 1 h;

Steps:

VIII
33 mL (52.8 mMol) n-butyllithium (1.6 M in hexane)were added dropwise to a solution 10 gm (48.1 mMol) tetrahydropyran-2-yl 3-methoxyphenyl ether in 100 mL tetrahydrofuran over 15 minutes. After stirring for 2.5 hours at room temperature, the reaction mixture was cooled to 0° C. and then 4.6 mL (53.2 mMol) 1,2-dibromoethane were added dropwise. The reaction mixture was then allowed to stir at room temperature for about 14 hours. The reaction mixture was then diluted with 50 mL 1 N hydrochloric acid and was stirred for 1 hour. The aqueous phase was extracted with three 100 mL portions of diethyl ether. The organic phases were combined and extracted well with 5 N sodium hydroxide. These basic aqueous extracts were combined and cooled in an ice/water bath. The pH of this aqueous solution was adjusted to about 1 with 5 N hydrochloric acid and then extracted with three 100 mL portions of diethyl ether. These ether extracts were combined and washed with saturated aqueous sodium chloride, dried over magnesium sulfate and concentrated under reduced pressure. The resulting residue was subjected to silica gel chromatography, eluting with a gradient of hexane containing from 0 to 10% ethyl acetate. Fractions containing the desired compound were combined and concentrated under reduced pressure to provide 2.91 gm (30%) of a residue which crystallized upon standing.EA: Calculated for C₇H₇BrO₂: Theory: C, 41.41; H, 3.48. Found: C, 41.81; H, 3.46.

References:

Eli Lilly and Company US7045545, 2006, B1 Location in patent:Page/Page column 22