2-Bromo-3-methyl-5-chloropyridine synthesis

1synthesis methods

Yield:-

Reaction Conditions:

with hydrogen bromide;bromine;sodium nitrite1.) chlorination; 2.) water, -10 deg C, 1.5 h, 0 deg C, 0.5 h;Multistep reaction;

References:

Ife;Catchpole;Durant;Ganellin;Harvey;Meeson;Owen;Parsons;Slingsby;Theobald [European Journal of Medicinal Chemistry,1989,vol. 24,# 3,p. 249 - 258]

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