2-Bromo-3-methylbenzoyl chloride synthesis
- Product Name:2-Bromo-3-methylbenzoyl chloride
- CAS Number:121794-40-9
- Molecular formula:C8H6BrClO
- Molecular Weight:233.49
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Yield:121794-40-9 100%
Reaction Conditions:
with oxalyl dichloride in dichloromethane at 0 - 50; for 4 h;
Steps:
93.a Example 93; a) Preparation of 2-BROMO-3-METHYLBENZOYL CHLORIDE
6.0 g (27.9 MMOL, 1.0 eq) of 2-bromo-3-methylbenzoic acid are dissolved in 140 ml of DICHLOROMETHANE, and 7.3 g, 5.0 ml (83.7 MMOL ; 3.0 eq) of oxalyl chloride are then added to the reaction medium maintained at 0°C. The solution is then heated to 50°C and maintained at this temperature for four hours, after which the reaction medium is concentrated under reduced pressure for one hour. The infrared spectrum of the product obtained shows a peak revealing the car- BONYL function of the acid chloride at 1777 CM-1. The product is obtained in quan- titative yield and is used without further modification (6.5 g; 100%).
References:
WO2004/37806,2004,A1 Location in patent:Page 68
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