ChemicalBook CAS DataBase List 2'-BROMO-4-CHLORO-BIPHENYL

2'-BROMO-4-CHLORO-BIPHENYL synthesis

10synthesis methods

Product Name:2'-BROMO-4-CHLORO-BIPHENYL
CAS Number:179526-95-5
Molecular formula:C12H8BrCl
Molecular Weight:267.55

583-55-1
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1679-18-1 Synthesis

1679-18-1
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179526-95-5
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$23.00/1g

Yield:179526-95-5 94%

Reaction Conditions:

with tetrakis-(triphenylphosphine)-palladium;potassium carbonate in ethanol;lithium hydroxide monohydrate;toluene at 80; for 4 h;Inert atmosphere;

Steps:

1.4 Intermediate E was synthesized by Reaction Scheme 4-1 below:

In an argon atmosphere, in a 1 L three-neck flask, 1-bromo-2-iodobenzene (25.0 g), 4-chlorophenylboronic acid (13.8 g), Pd(PPh₃)₄(5.1 g), and K₂CO₃(24.4 g) were added and dissolved in a mixed solvent of toluene, water, and ethanol (10:2:1, 350 mL), and the mixture was heated and stirred at about 80° C. for about 4 hours. The resultant mixture was extracted with CH₂Cl₂by adding water to obtain organic layers. The obtained organic layers were combined and dried over MgSO₄, and the solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography to obtain Intermediate E (22.1 g, yield: 94%). The molecular weight of Intermediate E measured by FAB-MS measurement was 267.

References:

US2022/131079,2022,A1 Location in patent:Paragraph 0204; 0218-0220

1679-18-1 Synthesis

1679-18-1
610 suppliers
$10.00/1g